CAS No. : 1233948-61-2

Price and Availability of CAS No. : 1233948-61-2
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Cat. No. : HY-16187
M.Wt: 384.47
Formula: C19H16N2O3S2
Purity: >98 %
Solubility: DMSO : ≥ 36 mg/mL (93.64 mM)
Introduction of 1233948-61-2 :

EL102 is a inhibitor of HIF1α , Which can inhibit tubulin polymerisation and decreased microtubule stability. target: HIF1α IC 50:20-40 nM.[1] in vitro : EL102 is a cytotoxic agent and also displays cytostatic properties, through flow cytometric analysis of PI-stained cells cultured for 24, 48 and 72 h, following treatment. EL102 induces apoptosis and causes G2/M arrest, preventing the cell from entering into mitosis. In vivo: CWR22 tumours were taken from an in vivo passage, cut into small fragments and transplanted subcutaneously (s.c.) into the flank of 48 nude mice. At day 13, when the tumours were palpable, mice were randomised into 10 groups with 8 mice each and treatment initiated. EL102 12 mg kg 1 via p.o. (0700 hours and 1700 hours daily).[1]

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