PF-04979064


CAS No. : 1220699-06-8

1220699-06-8
Price and Availability of CAS No. : 1220699-06-8
Size Price Stock
5mg $96 In-stock
10mg $156 In-stock
25mg $348 In-stock
50mg $624 In-stock
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Cat. No. : HY-100398
M.Wt: 446.50
Formula: C24H26N6O3
Purity: >98 %
Solubility: DMSO : 11 mg/mL (24.64 mM; Need ultrasonic and warming)
Introduction of 1220699-06-8 :

PF-04979064 is a potent and selective PI3K/mTOR dual kinase inhibitor with Kis of 0.13 nM and 1.42 nM for PI3Kα and mTOR, respectively. IC50 & Target: Ki: 0.13 nM (PI3Kα), 1.42 nM (mTOR)[1] In Vitro: PF-04979064 is tested against human class I PI3K isoforms PI3Kα, PI3Kγ, and PI3Kδ, with PI3Kα Ki of 0.13 nM, PI3Kγ Ki of 0.111 nM, and PI3Kδ Ki of 0.122 nM[1]. In Vivo: PF-04979064 is progressed to rat in vivo PK studies and exhibits robust PK profile: Vdss=5.23 L/kg, Cl=19.3 mL/min/kg, T1/2=1.85 h, and F%=61%[1].

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