Ubiquitin Isopeptidase Inhibitor I, G5


CAS No. : 108477-18-5

(Synonyms: NSC144303)

108477-18-5
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Cat. No. : HY-100738
M.Wt: 414.39
Formula: C19H14N2O7S
Purity: >98 %
Solubility: DMSO : 50 mg/mL (120.66 mM; Need ultrasonic); THF : 3.44 mg/mL (8.30 mM; Need ultrasonic); Ethanol : < 1 mg/mL (ultrasonic) (insoluble); Acetone : 2.86 mg/mL (6.90 mM; Need ultrasonic)
Introduction of 108477-18-5 :

Ubiquitin Isopeptidase Inhibitor I, G5 (NSC 144303) is an apoptosome-independent caspase and apoptosis activator with IC50 values of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively. IC50 & Target: IC50: 1.76 μM (E1A cells), 1.6 μM (E1A/C9DN cells)[1] In Vitro: G5 is capable of activating an apoptosome-independent apoptotic pathway. It targets the ubiquitinproteasome system by inhibiting the ubiquitin isopeptidases. G5 induces a rather unique apoptotic pathway, which includes a Bcl-2-dependent but apoptosome-independent mitochondrial pathway with upregulation of the BH3-only protein Noxa, stabilization of the inhibitor of apoptosis antagonist Smac, but also the involvement of the death receptor pathway. G5 is a potent apoptotic inducer showing IC50s of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively[1].

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