JH-X-119-01 (hydrochloride)
CAS No. : 2591344-30-6
| Size | Price | Stock |
|---|---|---|
| 1mg | $150 | In-stock |
| 5mg | $520 | In-stock |
| 10mg | $850 | In-stock |
| 50mg | $3300 | In-stock |
| 100 mg | Get quote | |
| 200 mg | Get quote | |
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| Cat. No. : | HY-103017 |
| M.Wt: | 488.93 |
| Formula: | C25H21ClN6O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (102.26 mM; Need ultrasonic); H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble) |
JH-X-119-01 hydrochloride is a potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 hydrochloride ameliorates LPS-induced sepsis in mice[1]. In Vitro: Jh-X-119-01 (10 μM) decreases phosphorylation of NF-κB and mRNA levels of IL-6 and TNFα in LPS-treated macrophages in vitro. Jh-X-119-01 selectively inhibits IRAK1 phosphorylation[1]. In Vivo: Jh-X-119-01 improves survival and decreases immunopathies of LPS-challenged mice. Jh-X-119-01 increases survival of mice at the dose of 5 mg/kg body weight. Survival is further improved when the dose is increased to 10 mg/kg[1].
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Inquiry Information- Product Name:
- JH-X-119-01 (hydrochloride)
- Cat. No.:
- HY-103017
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