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 MRT68921 (hydrochloride)

HY-100006A  Technical Data: Price and Availability of HY-100006A

HY-100006A M.Wt: 471.038
HY-100006A Formula: C25H35ClN6O
HY-100006A Purity: >98 %
HY-100006A Storage: at 20℃ 2 years
HY-100006A Solubility: H<sub>2</sub>O: 10 mg/mL
HY-100006A Name: MRT68921 (hydrochloride)
5mg/$60 In-stock
10mg/$100 In-stock
25mg/$200 In-stock
50mg/$360 In-stock
100mg/$470 In-stock
200mg/$850 In-stock
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MRT68921 (hydrochloride)  Data Sheet:
Introduction of MRT68921 (hydrochloride) :
MRT68921 hydrochloride is the most potent inhibitor of both ULK1 and ULK2, with greater than a 15-fold reduction in the IC50 for ULK1 (2.9 nM) and greater than a 30-fold reduction for ULK2 (1.1 nM). IC50 value: 2.9/1.1 nM (ULK1/2) Target: ULK in vitro: MRT68921 potently inhibits ULK1 and ULK2 and block autophagy in cells. MRT68921 specifically blocks autophagic flux through ULK1 inhibition. MRT68921 is able to inhibit the WT-restored ATG13 phosphorylation and autophagy similarly to cells expressing endogenous ULK1. [1]
References on MRT68921 (hydrochloride) :

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