MRT68921 (hydrochloride)

Price and Availability of HY-100006A
Size Price Stock
5mg $60 In-stock
10mg $100 In-stock
25mg $200 In-stock
50mg $360 In-stock
100mg $470 In-stock
200mg $850 In-stock
500 mg Get quote
1 g Get quote
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Cat. No. : HY-100006A
M.Wt: 471.04
Formula: C25H35ClN6O
Purity: >98 %
Storage: at -20℃ 3 years
Solubility: H2O: 10 mg/mL
Introduction of :

MRT68921 hydrochloride is the most potent inhibitor of both ULK1 and ULK2, with greater than a 15-fold reduction in the IC50 for ULK1 (2.9 nM) and greater than a 30-fold reduction for ULK2 (1.1 nM). IC50 value: 2.9/1.1 nM (ULK1/2) Target: ULK in vitro: MRT68921 potently inhibits ULK1 and ULK2 and block autophagy in cells. MRT68921 specifically blocks autophagic flux through ULK1 inhibition. MRT68921 is able to inhibit the WT-restored ATG13 phosphorylation and autophagy similarly to cells expressing endogenous ULK1. [1]

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