Fumarate hydratase-IN-2 (sodium salt)

Price and Availability of HY-100005A
Size Price Stock
1mg $180 In-stock
5mg $420 In-stock
10mg $600 In-stock
25mg $1200 In-stock
50mg $1920 In-stock
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Cat. No. : HY-100005A
M.Wt: 440.47
Formula: C25H25N2NaO4
Purity: >98 %
Storage: at 20℃ 2 years
Solubility: DMSO : 10.66 mg/mL (24.20 mM; Need ultrasonic and warming)
Introduction of Fumarate hydratase-IN-2 (sodium salt) :

Fumarate hydratase-IN-2 sodium salt is an enzyme of the TCA cycle and cell-permeable inhibitor. (1) inhibition of fumarate hydratase can contribute to tumorigenicity in some cells. (2) The use of a photoaffinity labeling strategy identified fumarate hydratase as the principal pharmacological target. Final biochemical studies confirmed dose-dependent, competitive inhibition of this enzyme (3) Chemical inhibition of fumarate hydratase renders cells highly dependent on glucose metabolism for survival.

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