Size | Price | Stock |
---|---|---|
5mg | $245 | In-stock |
10mg | $380 | In-stock |
50mg | $980 | In-stock |
100 mg | Get quote | |
200 mg | Get quote | |
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Cat. No. : | HY-100556 |
M.Wt: | 439.53 |
Formula: | C26H21N3O2S |
Purity: | >98 % |
Solubility: | DMSO : 17.86 mg/mL (40.63 mM; Need ultrasonic) |
Tie2 kinase inhibitor 1 (compound 5) is a potent, selective Tie2 kinase inhibitor with an IC50 of 250 nM[1]. Tie2 kinase inhibitor 1 has anti-cancer activity[2].
IC50 & Target: IC50: 250 nM (Tie2)[1]
In Vitro: Tie2 kinase inhibitor 1 (compound 5) has an IC50 of 50 μM for p38 and has moderate to excellent cellular activities (cell IC50=232 nM)[1].
Tie2 kinase inhibitor 1 inhibits tunica internal endothelial cell kinase 2 (Tie2)[2].
In Vivo: Tie2 kinase inhibitor 1 (intraperitoneally; 50 mg/kg; twice a week for 6 weeks) results in statistically significant reductions in tumor volume by day 15. Tie2 kinase inhibitor 1 results in a 61% reduction in tumor volume by day 20, and reduces tumor volume by 45% by 6 weeks[1].
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