Tie2 kinase inhibitor 1


CAS No. : 948557-43-5

948557-43-5
Price and Availability of CAS No. : 948557-43-5
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5mg $245 In-stock
10mg $380 In-stock
50mg $980 In-stock
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Cat. No. : HY-100556
M.Wt: 439.53
Formula: C26H21N3O2S
Purity: >98 %
Solubility: DMSO : 17.86 mg/mL (40.63 mM; Need ultrasonic)
Introduction of 948557-43-5 :

Tie2 kinase inhibitor 1 (compound 5) is a potent, selective Tie2 kinase inhibitor with an IC50 of 250 nM[1]. Tie2 kinase inhibitor 1 has anti-cancer activity[2]. IC50 & Target: IC50: 250 nM (Tie2)[1] In Vitro: Tie2 kinase inhibitor 1 (compound 5) has an IC50 of 50 μM for p38 and has moderate to excellent cellular activities (cell IC50=232 nM)[1].
Tie2 kinase inhibitor 1 inhibits tunica internal endothelial cell kinase 2 (Tie2)[2].
In Vivo: Tie2 kinase inhibitor 1 (intraperitoneally; 50 mg/kg; twice a week for 6 weeks) results in statistically significant reductions in tumor volume by day 15. Tie2 kinase inhibitor 1 results in a 61% reduction in tumor volume by day 20, and reduces tumor volume by 45% by 6 weeks[1].

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