XL019
CAS No. : 945755-56-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $85 | In-stock |
| 10mg | $150 | In-stock |
| 50mg | $495 | In-stock |
| 100mg | $825 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-13775 |
| M.Wt: | 444.53 |
| Formula: | C25H28N6O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (56.24 mM; Need ultrasonic) |
XL019 is a potent, orally active, and selective JAK2 inhibitor, with IC50s of 2.2, 134.3, and 214.2 nM for JAK2, JAK1 and JAK3, respectively. XL019 shows 50-fold or greater selectivity for JAK2, versus a panel of over 100 serine/threonine and tyrosine kinases, including other members of the JAK family. XL019 potently inhibits STAT3 and STAT5 phosphorylation in cells harboring either JAK2V617F or wild-type JAK2[1][2].
In Vivo: XL019 (100-300 mg/kg; p.o.; twice daily for 14 days) inhibits HEL.92.1.7 xenograft tumor growth[1].
XL019 (10 mg/kg) treatment shows that the Cmax, t1/2 and Vd were 5.24 μM, 1.94 hours, 5.319 L/kg, respectively[1].
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