QS11
CAS No. : 944328-88-5
| Size | Price | Stock |
|---|---|---|
| 1mg | $51 | In-stock |
| 5mg | $99 | In-stock |
| 10mg | $160 | In-stock |
| 25mg | $320 | In-stock |
| 50mg | $480 | In-stock |
| 100mg | $720 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-12762 |
| M.Wt: | 567.68 |
| Formula: | C36H33N5O2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL (176.16 mM) |
QS11 is an inhibitor of ARFGAP1 (ADP-ribosylation factor GTPase-activating protein 1), with an EC50 of 1.5 µM. QS11 modulates Wnt/β-catenin signaling through an effect on protein trafficking. QS11 inhibits migration of ARFGAP overexpressing breast cancer cells[1].
IC50 & Target: EC50: 1.5 µM (ARFGAP1)[1]
In Vitro: QS11 binds and inhibits the GTPase activating protein of ARFGAP1, suggesting that QS11 modulates Wnt/β-catenin signaling through an effect on protein trafficking[1].
QS11 (2.5 μM) activates the Super(8X)TOPFlash reporter 200-fold in the presence of Wnt-3a conditioned medium, whereas Wnt-3a treatment alone increases reporter activity 40-fold[2].
QS11 shows potent activity (EC50=0.5 μM) with little cytotoxicity toward HEK293 and human primary fibroblast cells[2].
QS11 effectively reduces in vitro migration of metastatic human breast cancer cells[2].
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