JNJ-38877605


CAS No. : 943540-75-8

943540-75-8
Price and Availability of CAS No. : 943540-75-8
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5mg $55 In-stock
10mg $90 In-stock
50mg $250 In-stock
100mg $400 In-stock
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Cat. No. : HY-50683
M.Wt: 377.35
Formula: C19H13F2N7
Purity: >98 %
Solubility: DMSO : ≥ 30 mg/mL
Introduction of 943540-75-8 :

JNJ-38877605 is an orally active ATP-competitive inhibitor of c-Met with an IC50 of 4 nM, 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases[1][2]. JNJ-38877605 inhibits c-Met phosphorylation and regulates lipid accumulation. JNJ-38877605 can be used for tumor and metabolic disease reseach[3][4][5]. In Vitro:JNJ-38877605 (0.5 μΜ, 24 h) inhibits CPNE1 (HY-P70097)-induced activation of the MET signaling pathway in A549 cells[4].
JNJ-38877605 (JNJ) (5, 10, 20 μΜ, 2, 5, 8 days) inhibits c-Met phosphorylation and results in less lipid accumulation and triglyceride (TG) content with no cytotoxicity in 3T3-L1 cells[5].
In Vivo:JNJ-38877605 (50 mg/kg, p.o., once daily for 13 days) counteractes radiation-induced invasiveness, promotes apoptosis in tumor xenografts[2].
JNJ-38877605 (40 mg/kg, p.o., once daily for 3 days) decreases in plasma concentration of IL8, GROa, uPAR Met-addicted GTL16 xenografts mice model[3].

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