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HY-10997

CAS:936563-96-1

 (Synonyms  Ibrutinib;PCI32765;PCI 32765)
936563-96-1  Technical Data: Price and Availability of  Cas No:936563-96-1

Cas : 936563-96-1 M.Wt: 440.5
Cas : 936563-96-1 Formula: C25H24N6O2
Cas : 936563-96-1 Purity: >98 %
Cas : 936563-96-1 Storage: at 20℃ 2 years
Cas : 936563-96-1 Solubility: DMSO: ≥ 52 mg/mL
Cas : 936563-96-1 Name: PCI-32765
USD
1g/$540 In-stock
5mg/$50 In-stock
10mg/$65 In-stock
50mg/$120 In-stock
100mg/$150 In-stock
200mg/$240 In-stock
500mg/$440 In-stock
1g Get quote
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936563-96-1  Data Sheet:
 
Introduction of 936563-96-1 :
PCI-32765 is a selective, irreversible Btk inhibitor with IC50 value of 0.5 nM. IC50 & Target: IC50: 0.5 nM (Btk) In Vitro: PCI-32765 selectively inhibits B-cell signaling and activation. It inhibits autophosphorylation of Btk (IC50=11 nM), phosphorylation of Btk's physiological substrate PLCγ (IC50=29 nM), and phosphorylation of a further downstream kinase, ERK (IC50=13 nM)[1]. PCI-32765 inhibits BCR-activated primary B cell proliferation (IC50=8 nM). Following FcγR stimulation, PCI-32765 inhibits TNFα, IL-1β and IL-6 production in primary monocytes (IC50=2.6, 0.5, 3.9 nM, respectively)[3]. In Vivo: PCI-32765 (3.125-50 mg/kg, p.o.) reduces the level of circulating autoantibodies and completely suppresses disease in mice with collagen-induced arthritis. PCI-32765 inhibits autoantibody production and the development of kidney disease in the MRL-Fas(lpr) lupus model. PCI-32765 (3.125-50 mg/kg, p.o.) reduces renal disease and autoantibody production in MRL-Fas(lpr) mice[1]. PCI-32765 (0.1 μM) inhibits activation-induced proliferation of CLL cells, induces selective cytotoxicity in B cells compared with T cells, but alters activation induced T-cell cytokine production[2]. PCI-32765 dose-dependently and potently reverses arthritic inflammation in a therapeutic CIA model with an ED50 of 2.6 mg/kg/day. PCI-32765 also prevents clinical arthritis in CAIA models[3].
 
References on 936563-96-1 :
 

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