CAS:923564-51-6

(Synonyms ABT-263;ABT 263;ABT263)

923564-51-6 Technical Data:

Price and Availability of Cas No:923564-51-6

Cas : 923564-51-6 M.Wt: 974.6127
Cas : 923564-51-6 Formula: C47H55ClF3N5O6S3
Cas : 923564-51-6 Purity: >98 %
Cas : 923564-51-6 Storage: at 20℃ 2 years
Cas : 923564-51-6 Solubility: 10 mM in DMSO
Cas : 923564-51-6 Name: Navitoclax

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923564-51-6 Data Sheet:

Introduction of 923564-51-6 :
Navitoclax is a potent and orally bioavailable Bcl-2 family protein inhibitor that binds with high affinity (K_i < 1 nM) to multiple anti-apoptotic Bcl-2 family proteins including Bcl-x_L, Bcl-2 and Bcl-w. IC50 & Target: Ki: < 1 nM (Bcl-x_L), < 1 nM (Bcl-2), < 1 nM (Bcl-w) In Vitro: Navitoclax (ABT-263) is active against approximately one-half of the cell lines of the PPTP in vitro panel. The median IC₅₀?for all of the lines in the panel is 1.91 ?M^[1]. Navitoclax in combination with chemotherapy agents leads most ovarian cancer cell lines a synergistic response, and enhances the caspase activation at all paclitaxel doses tested in both SK-OV-3 and IGROV-1 cell lines^[2]. In Vivo: Navitoclax (100 mg/kg/day, p.o.) also improves responses to bendamustine-rituximab (BR) in a subset of tumours in mice xenograft^[3].

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