CAS No. : 923564-51-6

(Synonyms: ABT-263)

Price and Availability of CAS No. : 923564-51-6
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Cat. No. : HY-10087
M.Wt: 974.61
Formula: C47H55ClF3N5O6S3
Purity: >98 %
Storage: at 20℃ 2 years
Solubility: DMSO: ≥ 100 mg/mL
Introduction of 923564-51-6 :

Navitoclax is a potent and orally bioavailable Bcl-2 family protein inhibitor that binds with high affinity (Ki < 1 nM) to multiple anti-apoptotic Bcl-2 family proteins including Bcl-xL, Bcl-2 and Bcl-w. IC50 & Target: Ki: < 1 nM (Bcl-xL), < 1 nM (Bcl-2), < 1 nM (Bcl-w) In Vitro: Navitoclax (ABT-263) is active against approximately one-half of the cell lines of the PPTP in vitro panel. The median IC50 for all of the lines in the panel is 1.91 µM[1]. Navitoclax in combination with chemotherapy agents leads most ovarian cancer cell lines a synergistic response, and enhances the caspase activation at all paclitaxel doses tested in both SK-OV-3 and IGROV-1 cell lines[2]. In Vivo: Navitoclax (100 mg/kg/day, p.o.) also improves responses to bendamustine-rituximab (BR) in a subset of tumours in mice xenograft[3].

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