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HY-10087

CAS:923564-51-6

 (Synonyms  ABT-263)
923564-51-6  Technical Data: Price and Availability of  Cas No:923564-51-6

Cas : 923564-51-6 M.Wt: 974.6127
Cas : 923564-51-6 Formula: C47H55ClF3N5O6S3
Cas : 923564-51-6 Purity: >98 %
Cas : 923564-51-6 Storage: at 20℃ 2 years
Cas : 923564-51-6 Solubility: 10 mM in DMSO
Cas : 923564-51-6 Name: Navitoclax
USD
5mg/$50 In-stock
10mg/$80 In-stock
25mg/$140 In-stock
50mg/$200 In-stock
100mg/$350 In-stock
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923564-51-6  Data Sheet:
 
Introduction of 923564-51-6 :
Navitoclax is a potent and orally bioavailable Bcl-2 family protein inhibitor that binds with high affinity (Ki < 1 nM) to multiple anti-apoptotic Bcl-2 family proteins including Bcl-xL, Bcl-2 and Bcl-w. IC50 & Target: Ki: < 1 nM (Bcl-xL), < 1 nM (Bcl-2), < 1 nM (Bcl-w) In Vitro: Navitoclax (ABT-263) is active against approximately one-half of the cell lines of the PPTP in vitro panel. The median IC50?for all of the lines in the panel is 1.91 ?M[1]. Navitoclax in combination with chemotherapy agents leads most ovarian cancer cell lines a synergistic response, and enhances the caspase activation at all paclitaxel doses tested in both SK-OV-3 and IGROV-1 cell lines[2]. In Vivo: Navitoclax (100 mg/kg/day, p.o.) also improves responses to bendamustine-rituximab (BR) in a subset of tumours in mice xenograft[3].
 
References on 923564-51-6 :
 

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