Vonoprazan


CAS No. : 881681-00-1

(Synonyms: TAK-438 (free base))

881681-00-1
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Cat. No. : HY-100007
M.Wt: 345.39
Formula: C17H16FN3O2S
Purity: >98 %
Solubility: DMSO : 100 mg/mL (289.53 mM; Need ultrasonic)
Introduction of 881681-00-1 :

Vonoprazan (TAK-438 free base), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan inhibits H+,K+-ATPase activity in porcine gastric microsomes with an IC50 of 19 nM at pH 6.5. Vonoprazan is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease. Vonoprazan can be used for eradication of Helicobacter pylori[1][2][3]. IC50 & Target: IC50: 19 nM (porcine gastric H+,K+-ATPase, at pH 6.5)[2] In Vitro: Vonoprazan (0.1 nM-10 μM; 30 minutes) exhibits porcine gastric H+, K+-ATPase activity in a concentration-dependent manner[2].
Vonoprazan does not inhibit Na+,K+-ATPase activity, even at concentrations 500 times higher than their IC50 values against gastric H+,K+-ATPase activity[2].
In Vivo: Vonoprazan (1-4 mg/kg; p.o.) completely inhibits basal and 2-deoxy-D-glucose (200 mg/kg; s.c.)-stimulated gastric acid secretion at the 4 mg/kg dose in rats[2].

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