LOC14
CAS No. : 877963-94-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $55 | In-stock |
| 10mg | $105 | In-stock |
| 25mg | $231 | In-stock |
| 50mg | $418 | In-stock |
| 100mg | $737 | In-stock |
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| Cat. No. : | HY-100432 |
| M.Wt: | 317.41 |
| Formula: | C16H19N3O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (157.52 mM; ultrasonic and warming and heat to 60°C) |
LOC14 is a potent Protein disulfide isomerase (PDI) inhibitor with EC50 and Kd values of 500 nM and 62 nM, respectively. LOC14 exhibits high stability in mouse liver microsomes and blood plasma, low intrinsic microsome clearance, and low plasma-protein binding[1]. LOC14 inhibits PDIA3 activity, decreases intramolecular disulfide bonds and subsequent oligomerization (maturation) of HA in lung epithelial cells[3]. IC50 & Target: Kd: 62 nM (PDI)[1] In Vitro: LOC14 (0.01-100 μM; 24 hours) exhibits the capacity to inhibit recombinant (r)PDIA3 at an IC50 of approximately 5 μM[3]. In Vivo: LOC14 (orally administered by gavage; 20 mg/kg; once daily; 12-28 weeks) significantly improves motor function, attenuated brain atrophy and extended survival in the N171–82Q HD mice[2].
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