Size | Price | Stock |
---|---|---|
1mg | $138 | In-stock |
5mg | $290 | In-stock |
10mg | $460 | In-stock |
50 mg | Get quote | |
100 mg | Get quote | |
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Cat. No. : | HY-100405 |
M.Wt: | 358.41 |
Formula: | C18H23FN6O |
Purity: | >98 % |
Solubility: | DMSO : ≥ 100 mg/mL (279.01 mM) |
FTIDC is an orally active, noncompetitive, selective allosteric metabotropic glutamate receptor (mGluR) 1 antagonist with an IC50 of 5.8 nM for human mGluR1a. FTIDC has no species differences in its antagonistic activity on recombinant human, mouse, and rat mGluR1[1]. In Vitro: FTIDC inhibits L-glutamate-induced increases in intracellular Ca2+ concentrations, with IC50 values of 5.8 nM , 5.8 nM , 3.1 nM , 7.7 nM for human mGluR1a, rat mGluR1a, mouse mGluR1a, human mGluR1b in CHO cells, respectively[1]. In Vivo: FTIDC (i.p. or p.o.; 1-30 mg/kg) reduces the duration of face-washing behavior elicited in a dosedependent manner and the inhibitory effect is statistically significant at 10 and 30 mg/kg with i.p. and 30 mg/kg with p.o.[1].
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