PAP-1
CAS No. : 870653-45-5
(Synonyms: 5-(4-Phenoxybutoxy)psoralen)
| Size | Price | Stock |
|---|---|---|
| 5mg | $106 | In-stock |
| 10mg | $178 | In-stock |
| 25mg | $376 | In-stock |
| 50mg | $647 | In-stock |
| 100mg | $1096 | In-stock |
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| Cat. No. : | HY-10015 |
| M.Wt: | 350.36 |
| Formula: | C21H18O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (142.71 mM; Need ultrasonic) |
PAP-1 (5-(4-Phenoxybutoxy)psoralen) is a potent, selective, and orally active Kv1.3 blocker (EC50=2 nM). PAP-1 blocks Kv1.3 in a use-dependent manner and acts by preferentially binding to the C-type inactivated state of the channel. PAP-1 exhibits 23-fold selectivity over Kv1.5 (EC50=45 nM), and further displays 33- to 125-fold selectivity over all other Kv1-family channels. PAP-1 does not exhibit cytotoxic or phototoxic effects[1][2]. IC50 & Target: EC50: 2 nM (Kv1.3), 45 nM (Kv1.5)[1] In Vitro: PAP-1 (2-100 nM; 30 minutes) suppresses the proliferation of CCR7-TEM cells with IC50 of 10 nM[1]. In Vivo: PAP-1 (0.3-3 mg/kg; i.p.; three times daily for 48 hours) prevents delayed type hypersensitivity (DTH) in lewis rats[1].
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