T-26c
CAS No. : 869296-13-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $120 | In-stock |
| 10mg | $190 | In-stock |
| 25mg | $320 | In-stock |
| 50mg | $540 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-100518 |
| M.Wt: | 479.51 |
| Formula: | C24H21N3O6S |
| Purity: | >98 % |
| Solubility: | DMSO : 15.62 mg/mL (32.57 mM; Need ultrasonic) |
T-26c is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 6.75 pM and more than 2600-fold selectivity over the other related metalloenzymes[1]. IC50 & Target: IC50: 6.75 pM (MMP-13)[1] In Vitro: T-26c significantly inhibits the breakdown of collagen (87.4% inhibition at 0.1 μM) in IL-1β and oncostatin M stimulated cartilage[1]. In Vivo: T-26c is well absorbed in all species at the oral dose of 10–20 mg/kg. Oral administration of the disodium salt formulations of T-26c to guinea pigs results in significant increases in AUC (8357 ng h/mL) and Cmax (1445 ng/ mL) compared with those of the free acid T-26c (AUC = 6478 ng h/ mL and Cmax= 911 ng/mL)[1].
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