PT-262


CAS No. : 86811-36-1

86811-36-1
Price and Availability of CAS No. : 86811-36-1
Size Price Stock
5mg $120 In-stock
10mg $190 In-stock
25mg $380 In-stock
50mg $620 In-stock
100mg $980 In-stock
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Cat. No. : HY-100035
M.Wt: 276.72
Formula: C14H13ClN2O2
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 86811-36-1 :

PT-262 is a potent ROCK inhibitor with an IC50 value of around 5 μM. PT-262 induces the loss of mitochondrial membrane potential and elevates the caspase-3 activation and apoptosis. PT-262 inhibits the ERK and CDC2 phosphorylation via a p53-independent pathway. PT-262 blocks cytoskeleton function and cell migration. PT-262 has anti-cancer activity[1][2]. In Vitro: PT-262 (5-40 μM; 24 h) induces cytotoxicity and proliferation inhibition in human lung cancer cells[1].
PT-262 (2-20 μM; 4-24 h) induces caspase-3 activation, mitochondrial dysfunction and apoptosis in lung cancer cells[1].
PT-262 (10-20 μM; 24 h) induces the accumulation of G2/M phases in both the p53-wild type and p53-null lung cancer cells, and inhibits the phosphorylation of CDC2 proteins[1].
PT-262 (0-10 μM; 24 h) represses ERK phosphorylation in lung cancer cells[1].
PT-262 (2 μM; 24 h) induces the cytoskeleton alteration and cell elongation in lung carcinoma A549 cells[2].
PT-262 (2-10 μM; 6 h) significantly blocks the cell migration in a concentration-dependent manner[2].

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