E-mail  
Home
 
AboutUs
 
Service
 
Products
 
Order Information
 
Contact us
Insert title here
Featured Products
HY-10005  |  Flavopiridol
HY-10008  |  SNS-032
HY-10012  |  AZD-5438
HY-10014  |  R547
HY-10032  |  PF 477736
HY-10087  |  Navitoclax
HY-10128  |  ZM-447439
HY-10161  |  Tozasertib
HY-10180  |  MLN8054
HY-10192  |  NVP-TAE 684
HY-10228  |  Motesanib
HY-10249  |  GSK-690693
HY-10355  |  AKT inhibitor VIII
HY-10358  |  MK 2206 (dihydrochloride)
HY-10992  |  AZD-7762
HY-10997  |  PCI-32765
HY-11001  |  PHA-793887
HY-11002  |  CP-466722
HY-11007  |  GNF-2
HY-11009  |  CGP60474
more    
Products
-->
HY-10992

CAS:860352-01-8

 (Synonyms  AZD7762;AZD 7762)
860352-01-8  Technical Data: Price and Availability of  Cas No:860352-01-8

Cas : 860352-01-8 M.Wt: 362.42
Cas : 860352-01-8 Formula: C17H19FN4O2S
Cas : 860352-01-8 Purity: >98 %
Cas : 860352-01-8 Storage: at 20℃ 2 years
Cas : 860352-01-8 Solubility: 10 mM in DMSO
Cas : 860352-01-8 Name: AZD-7762
USD
5mg/$72 In-stock
10mg/$110 In-stock
50mg/$358 In-stock
100mg/$468 In-stock
1g Get quote
5g Get quote
>10g Get quote
We match the lowest price on market.
We offer a substantial discount on larger orders,please
inquire via sales@chemexpress.cn
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
Online Inquiry
 
860352-01-8  Data Sheet:
 
Introduction of 860352-01-8 :
AZD7762 is a potent and selective inhibitor of Chk1 with IC50 of 5 nM; equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck. IC50 Value: 5 nM Target: ChK in vitro: AZD-7762 is a novel checkpoint kinase inhibitor with an IC50 of 5 and <10 nM for CHK1 and CHK2, respectively. AZD7762, a more selective Chk1 inhibitor, inhibits Chk1 phosphorylation of a cdc25C peptide by reversibly binding to the ATP-binding site of Chk1, with IC50 of 5 nM and Ki of 3.6 nM. AZD7762 induces cell arrest with EC50 of 0.620 μM, and significantly abrogates the camptothecin induced G2 arrest with an EC50 of 10 nM, by blocking the chk1 dependent degradation of Cdc25A and activation of Cyclin A. AZD7762 (300 nM) enhances the antitumor efficacy of gemcitabine against SW620 and topotecan against MDA-MB-231 by reducing the GI50 values from 24.1 nM and 2.25 μM to 1.08 nM and 0.15 μM, respectively. AZD7762 shows cytotoxicity against a variety of neuroblastoma cell lines bearing p53 wild type, p53 mutation, Mdm2 amplification or p14 deletion with IC50 values ranging from 82.6-505.9 nM. in vivo: AZD-7762 significantly prolonged the median time required for tumor volume doubling in response to gemcitabine and radiation. AZD7762 alone at 25 mg/kg shows little antitumor activity in the H460-DNp53 xenograft mice and SW620 xenograft mice, but when administrated in combination with gemcitabine (60 mg/kg), AZD7762 shows significant antitumor efficacy in the two xenografts mice with a log cell kill of 0.9 or percent treated/control (%T/C) of 26 even at low dose of 12.5 mg. Dosing of AZD7762 in combination with gemcitabine (10 mg/kg) in the H460-DNp53 xenograft rat inhibits the tumor volume in a dose-dependent manner with the %T/C values of 48 and 32 for 10 and 20 mg/kg AZD7762, respectively. AZD7762 (25 mg/kg) in combination with irinotecan (25 or 50 mg/kg) causes complete tumor regression in the SW620 xenograft mice with the %T/C increasing significantly to -66% and -67%, respectively.
 
References on 860352-01-8 :
 

Keywords: buy AZD-7762 | AZD-7762 Supplier | purchase AZD-7762 | AZD-7762 cost | AZD-7762 manufacturer | order AZD-7762 | AZD-7762 distributor | AZD-7762 structure
buy 860352-01-8 | 860352-01-8 Supplier | purchase 860352-01-8 | 860352-01-8 cost | 860352-01-8 manufacturer | order 860352-01-8 | 860352-01-8 distributor | 860352-01-8 structure
Insert title here
 
Products are for research use only. Not for human use. We do not sell to patients.           Copyright © 2009 Haoyuan Chemexpress All Rights Reserved
ADDRESS: 6/F, No. 2 Building, No. 720,Cailun Road, Shanghai, P.R.China  
TEL:
86-21-58998590   FAX: 86-21-53700326, 86-21-58998590   E-mail: sales@chemexpress.cn