O-Desmethyl gefitinib


CAS No. : 847949-49-9

847949-49-9
Price and Availability of CAS No. : 847949-49-9
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Cat. No. : HY-100064
M.Wt: 432.88
Formula: C21H22ClFN4O3
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 847949-49-9 :

O-Desmethyl gefitinib is an active metabolite of Gefitinib in human plasma. The formation of O-desmethyl gefitinib is dependent on CYP2D6 activity. O-desmethyl gefitinib inhibits EGFR with an IC50 of 36 nM in subcellular assays[1][2]. IC50 & Target:IC50: 36 nM (EGFR)[2]

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