E-mail  
Home
 
AboutUs
 
Service
 
Products
 
Order Information
 
Contact us
Insert title here
Featured Products
HY-10372  |  PP121
HY-10005  |  Flavopiridol
HY-10008  |  SNS-032
HY-10087  |  Navitoclax
HY-10161  |  Tozasertib
HY-10162  |  Olaparib
HY-10180  |  MLN8054
HY-10192  |  NVP-TAE 684
HY-10193  |  AZD-1480
HY-10249  |  GSK-690693
HY-10254  |  PD0325901
HY-10355  |  AKT inhibitor VIII
HY-10358  |  MK 2206 (dihydrochloride)
HY-10997  |  PCI-32765
HY-11001  |  PHA-793887
HY-11002  |  CP-466722
HY-11007  |  GNF-2
HY-30237  |  Roscovitine
HY-50662  |  A-769662
HY-50767  |  Palbociclib
more    
Products
HY-50662

CAS:844499-71-4

844499-71-4  Technical Data: Price and Availability of  Cas No:844499-71-4

Cas : 844499-71-4 M.Wt: 360.3859
Cas : 844499-71-4 Formula: C20H12N2O3S
Cas : 844499-71-4 Purity: >98 %
Cas : 844499-71-4 Storage: at 20℃ 2 years
Cas : 844499-71-4 Solubility: DMSO: 24 mg/mL
Cas : 844499-71-4 Name: A-769662
USD
5mg/$50 In-stock
10mg/$70 In-stock
50mg/$250 In-stock
100mg/$450 In-stock
200mg/$760 In-stock
500mg/$1600 In-stock
1g Get quote
5g Get quote
>10g Get quote
We match the lowest price on market.
We offer a substantial discount on larger orders,please
inquire via sales@chemexpress.cn
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
Online Inquiry
 
844499-71-4  Data Sheet:
 
Introduction of 844499-71-4 :
A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM, and has little effect on GPPase/FBPase activity. IC50 & Target: EC50: 0.8 μM (AMPK) In Vitro: A-769662 is equally potent in activating the baculovirus expressed α1,β1,γ1 recombinant isoform of AMPK (EC50=0.7 μM). A-769662 and A-592107 activate AMPK purified from multiple tissues and species in a dose-responsive manner with modest variations in observed EC50s. EC50s determined for A-769662 using partially purified AMPK extracts from rat heart, rat muscle, or human embryonic kidney cells (HEKs) are 2.2 μM, 1.9 μM, or 1.1 μM, respectively[1]. A-769662 activates endogenous AMPK in LKB1-expressing (HEK293) and LKB1-deficient (CCL13) cells. A-769662 allosterically activates AMPK complexes containing γ1 harboring a substitution of arginine residue 298 to glycine (R298G). A-769662 inhibits dephosphorylation of Thr-172 in the mutant γ1-containing complexes to a similar degree as seen in the wild-type complexes[2]. A769662 (300 μM) has toxic effects on MEF cells. A769662 reversibly inhibits the proteasomal activity[3]. In Vivo: A-769662 (30 mg/kg, i.p.) significantly reduced the respiratory exchange ratio (RER) in the SD rat. There are 33% and 58% reductions of malonyl CoA levels in livers of animals treated with 30 mg/kg A-769662 (0.905 nmol/g) or 500 mg/kg metformin (0.574 nmol/g), respectively. A-769662 (30 mg/kg, b.i.d.) significantly decreases fed plasma glucose (30%-40% reduction), while the lower doses (3 and 10 mg/kg) of A-769662 had no effect on the in diabetic ob/ob mice[1].
 
References on 844499-71-4 :
 

Keywords: buy A-769662 | A-769662 Supplier | purchase A-769662 | A-769662 cost | A-769662 manufacturer | order A-769662 | A-769662 distributor | A-769662 structure
buy 844499-71-4 | 844499-71-4 Supplier | purchase 844499-71-4 | 844499-71-4 cost | 844499-71-4 manufacturer | order 844499-71-4 | 844499-71-4 distributor | 844499-71-4 structure
Insert title here
 
Products are for research use only. Not for human use. We do not sell to patients.           Copyright © 2009 Haoyuan Chemexpress All Rights Reserved
ADDRESS: 6/F, No. 2 Building, No. 720,Cailun Road, Shanghai, P.R.China  
TEL:
86-21-58998590   FAX: 86-21-53700326, 86-21-58998590   E-mail: sales@chemexpress.cn