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844499-71-4  Technical Data: Price and Availability of  Cas No:844499-71-4

Cas : 844499-71-4 M.Wt: 360.3859
Cas : 844499-71-4 Formula: C20H12N2O3S
Cas : 844499-71-4 Purity: >98 %
Cas : 844499-71-4 Storage: at 20℃ 2 years
Cas : 844499-71-4 Solubility: DMSO: 24 mg/mL
Cas : 844499-71-4 Name: A-769662
5mg/$50 In-stock
10mg/$70 In-stock
50mg/$250 In-stock
100mg/$450 In-stock
200mg/$760 In-stock
500mg/$1600 In-stock
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844499-71-4  Data Sheet:
Introduction of 844499-71-4 :
A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM, and has little effect on GPPase/FBPase activity. IC50 & Target: EC50: 0.8 μM (AMPK) In Vitro: A-769662 is equally potent in activating the baculovirus expressed α1,β1,γ1 recombinant isoform of AMPK (EC50=0.7 μM). A-769662 and A-592107 activate AMPK purified from multiple tissues and species in a dose-responsive manner with modest variations in observed EC50s. EC50s determined for A-769662 using partially purified AMPK extracts from rat heart, rat muscle, or human embryonic kidney cells (HEKs) are 2.2 μM, 1.9 μM, or 1.1 μM, respectively[1]. A-769662 activates endogenous AMPK in LKB1-expressing (HEK293) and LKB1-deficient (CCL13) cells. A-769662 allosterically activates AMPK complexes containing γ1 harboring a substitution of arginine residue 298 to glycine (R298G). A-769662 inhibits dephosphorylation of Thr-172 in the mutant γ1-containing complexes to a similar degree as seen in the wild-type complexes[2]. A769662 (300 μM) has toxic effects on MEF cells. A769662 reversibly inhibits the proteasomal activity[3]. In Vivo: A-769662 (30 mg/kg, i.p.) significantly reduced the respiratory exchange ratio (RER) in the SD rat. There are 33% and 58% reductions of malonyl CoA levels in livers of animals treated with 30 mg/kg A-769662 (0.905 nmol/g) or 500 mg/kg metformin (0.574 nmol/g), respectively. A-769662 (30 mg/kg, b.i.d.) significantly decreases fed plasma glucose (30%-40% reduction), while the lower doses (3 and 10 mg/kg) of A-769662 had no effect on the in diabetic ob/ob mice[1].
References on 844499-71-4 :

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