Quinacrine
CAS No. : 83-89-6
(Synonyms: Acriquine)
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| Cat. No. : | HY-13735 |
| M.Wt: | 399.96 |
| Formula: | C23H30ClN3O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Quinacrine (Acriquine) is an antimalarial and anti-cancer agent. Quinacrine also inhibits human aldehyde oxidase (IC50: 3.3 μM). Quinacrine has affinity for nucleic acids, and stains DNA and RNA in fixed cells (Ex/Em: 436/525 nm)[1][2][3][4][7].
In Vitro:Quinacrine inhibits human and rabbit aldehyde oxidase, with IC50s of 3.3 μM and 10 μM respectively[2].
Quinacrine blocks voltage-dependent sodium channels (IC50: 3.3 μM)[3].
Quinacrine (100 μM) is also a PLA2 inhibitor[4].
Quinacrine (0-20 μM, 24 h) inhibits the growth of SGC-7901 cells, and induces cell apoptosis[7].
In Vivo:Quinacrine (3-30 mg/kg, i.p., once daily for three days) has protective effect against glycerol-induced acute kidney injury in rats[5].
Quinacrine (2.5-10 mg/kg, i.p., once daily for eight weeks) has protective effect against Cyclosporine-induced nephrotoxicity in rats[6].
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