JNJ-17203212


CAS No. : 821768-06-3

821768-06-3
Price and Availability of CAS No. : 821768-06-3
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5mg $80 In-stock
10mg $140 In-stock
25mg $300 In-stock
50mg $520 In-stock
100mg $920 In-stock
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Cat. No. : HY-100129
M.Wt: 419.32
Formula: C17H15F6N5O
Purity: >98 %
Storage: at -20℃ 3 years
Solubility: 10 mM in DMSO
Introduction of 821768-06-3 :

JNJ-17203212 is a novel and selective TRPV1 antagonist, with IC50 of 65 nM and 102 nM for human TRPV1 and rat TRPV1. IC50 value: 65 nM (human TRPV1), 102 nM (rat TRPV1) Target: TRPV in vivo: JNJ-17203212 reduces sensitivity to luminal distension in both an acute, noninflammatory and a chronic, post-inflammatory rodent model of colonic hypersensitivity. Throughout this study, colonic sensitivity was assessed via quantification of VMR to CRD in rats following a single, oral administration of JNJ-17203212 (3, 10 or 30 mg/kg) or vehicle. [1] Oral pretreatment with JNJ-17203212 is a novel and selective TRPV1 antagonist, with partially prevents core hypothermia evoked by sc capsaicin. Oral pretreatment with JNJ-17203212 is a novel and selective TRPV1 antagonist, with partially prevents capsaicin-evoked hypothermia in a dose-response manner. [2]

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