Vibunazole


CAS No. : 80456-55-9

(Synonyms: BAY-N-7133)

80456-55-9
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Cat. No. : HY-100121
M.Wt: 309.79
Formula: C15H20ClN3O2
Purity: >98 %
Storage: at 20℃ 2 years
Solubility: DMSO
Introduction of 80456-55-9 :

Vibunazole is a new antifungal azole. In Vitro: Vibunazole is an antifungal azole. Low concentrations of all three drugs inhibit Coccidioides immitis, strain Silveira, in vitro with a descending order of activity ketoconazole>Vibunazole>BAY 1 9139[1]. In Vivo: The untreated, infected mice lost weight initially and progressively, whereas treated mice gain weight after an initial loss with Vibunazole (all doses), BAY 1 9139 and ketoconazole at 2.5 mg/kg/day. With both Vibunazole and BAY 1 9139, the 5 and 10 mg/kg doses yield serum concentrations exceeding the MICs for the Coccidioides immitis test strain (0.8 and 1.5 μg/mL respectively) for periods in excess of 30 min after injection[1].

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