Size | Price | Stock |
---|---|---|
5mg | $144 | In-stock |
10mg | $252 | In-stock |
50mg | $780 | In-stock |
100mg | $1140 | In-stock |
200 mg | Get quote | |
500 mg | Get quote | |
We match the lowest price on market. |
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Cat. No. : | HY-100463 |
M.Wt: | 253.08 |
Formula: | C12H6Cl2O2 |
Purity: | >98 % |
Solubility: | H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble); DMSO : 50 mg/mL (197.57 mM; Need ultrasonic) |
TPI-1, also known as Tyrosine Phosphatase Inhibitor 1, is a SHP-1 inhibitor; inhibits recombinant SHP-1 with an IC50 of 40 nM. IC50 & Target: IC50: 40 nM (recombinant SHP-1)[1] In Vitro: SHP-1 has been implicated as a potential cancer therapeutic target. TPI-1 is effective starting at 10 ng/mL in increasing SHP-1 phospho-substrates pLck-pY394. TPI-1 selectively increases SHP-1 phospho-substrates (pLck-pY394, pZap70 and pSlp76) in Jurkat T cells but has little effects on pERK1/2 or pLck-pY505. TPI-1 induces mouse splenic-IFNγ+ cells and induces IFNγ+ cells in human peripheral blood[1]. In Vivo: TPI-1 inhibits the growth of B16 melanoma tumors in mice at a tolerated oral dose in a T cell-dependent manner but has little effects on B16 cell growth in culture. TPI-1 thus also increases pLck-pY394 and IFNγ+ cells in mice. TPI-1 also inhibits B16 tumor growth and prolongs tumor mice survival as a tolerated s.c. agent[1].
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