JDTic (dihydrochloride)
CAS No. : 785835-79-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $140 | In-stock |
| 10mg | $230 | In-stock |
| 25mg | $550 | In-stock |
| 50mg | $980 | In-stock |
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| Cat. No. : | HY-10487 |
| M.Wt: | 538.55 |
| Formula: | C28H41Cl2N3O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (185.68 mM; Need ultrasonic); H2O : 50 mg/mL (92.84 mM; Need ultrasonic) |
JDTic (dihydrochloride) is a potent antagonist of kappa-opioid receptors (KOR), blocking the κ-agonist U50, 488-induced antinociception. In Vivo: JDTic (2.5-16 mg/kg, s.c.) dose-dependently blocks the antinociceptive response of nicotine in the tail-flick test but has no effect in the hot-plate assay or body temperature assessments at any dose tested in the mice injected with nicotine[1]. JDTic (3 mg/kg, i.p.) is capable of reversing anxiety-like behavior in the rat model of hangover anxiety. JDTic (10 mg/kg, i.p.) decreases alcohol self-administration, suppresses cue-induced reinstatement of alcohol seeking, and specifically blocks the effects of a KOR agonist at the 2 h pretreatment time point[2]. JDTic (30 mg/kg, i.g.) significantly blockes U50,488-induced diuresis immediately in rats[3].
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