JTT 551
CAS No. : 776309-04-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $620 | In-stock |
| 10mg | $980 | In-stock |
| 25mg | $1950 | In-stock |
| 50mg | $3250 | In-stock |
| 100mg | $5200 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-19779 |
| M.Wt: | 605.85 |
| Formula: | C34H43N3O3S2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
JTT 551 is selective a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with Kis of 0.22 μM and 9.3 μM for PTP1B and TCPTP (T-cell protein tyrosine phosphatase), respectively; JTT 551 can be used in the research of type 2 diabetes mellitus. IC50 & Target:IC50: 0.22 μM (PTP1B), 9.3 μM (TCPTP)[1] In Vitro: JTT 551 is selective a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with Kis of 0.22 μM and 9.3 μM for PTP1B and TCPTP (T-cell protein tyrosine phosphatase), respectively. JTT 551 shows low affinity at CD45 PTP (CD45) and leucocyte common antigen-related (LAR) PTP with Kis of both >30 μM. Furthermore, JTT-551 (10 and 30 μM) enhances the insulin-induced deoxyglucose uptake in a dosedependent manner[1]. In Vivo: JTT 551 (3 mg/kg, 30 mg/kg, p.o.) dose-dependently decreases blood glucose level on Days 7, 14 and 28 in db/db Mice. JTT 551 also significantly reduces triglyceride (TG) level at 30 mg/kg on Day 7 but does not alter insulin and total cholesterol (TC) levels[1].
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