CAS No. : 763113-22-0

(Synonyms: AZD2281;KU0059436)

Price and Availability of CAS No. : 763113-22-0
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10mg $60 In-stock
50mg $84 In-stock
100mg $108 In-stock
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500mg $216 In-stock
1g $300 In-stock
2g $540 In-stock
5g $1020 In-stock
10g $1920 In-stock
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Cat. No. : HY-10162
M.Wt: 434.46
Formula: C24H23FN4O3
Purity: >98 %
Storage: at 20℃ 2 years
Solubility: DMSO: 29 mg/mL
Introduction of 763113-22-0 :

Olaparib is a potent PARP inhibitor with IC50 of 5 and 1 nM for PARP-1 and PARP-2, respectively. IC50 & Target: IC50: 5/1 nM (PARP-1/2)[1] In Vitro: Olaparib (AZD2281) is a single digit nanomolar inhibitor of both PARP-1 and PARP-2 that shows standalone activity against BRCA1-deficient breast cancer cell lines. Olaparib is applied to SW620 cell lysates, and identified the IC50 for PARP-1 inhibition to be around 6 nM and the total ablation of PARP-1 activity to be at concentrations of 30−100 nM[1]. In Vivo: Animals bearing SW620 xenografted tumors are treated with Olaparib (10 mg/kg, p.o.) in combination with Temozolomide (TMZ) (50 mg/kg, p.o.) once daily for 5 consecutive days, after which the tumors are left to grow out[1]. Olaparib increases vascular perfusion in Calu-6 tumors established in a DWC model. Administration of olaparib(50 mg/kg, p.o.) as a single agent (top panel) or in combination with radiation (bottom panel) results in an increase in fluorescence intensity in the Calu-6 tumors[2].

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