JSH-23
CAS No. : 749886-87-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $106 | In-stock |
| 10mg | $150 | In-stock |
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| Cat. No. : | HY-13982 |
| M.Wt: | 240.34 |
| Formula: | C16H20N2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 56 mg/mL (233.00 mM) |
JSH-23 is an NF-κB inhibitor which inhibits NF-κB transcriptional activity with an IC50 of 7.1 μM in lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7. JSH-23 inhibits nuclear translocation of NF-κB p65 without affecting IκBα degradation[1].
IC50 & Target:IC50: 7.1 μM (NF-κB)
In Vitro:JSH-2 (1-300 μM; 24 hours) at <100 μM does not show significant cytotoxic effects on the RAW 264.7 cells[1].
Nuclear amount of NF-κB p65 is markedly increased upon exposure to LPS for 1 h. Treatment of JSH-23 (30 μM; 1 hours) to LPS- stimulated RAW 264.7 cells decreases nuclear content of NF-κB p65 in a dose-dependent manner[1].
In Vivo:JSH-23 (1 mg/kg, 3 mg/kg; orally administered; daily; for 2 weeks) significantly reverses the nerve conduction and nerve blood flow deficits seen in diabetic rats[2].
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