JNJ-10397049
CAS No. : 708275-58-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $132 | In-stock |
| 10mg | $220 | In-stock |
| 25mg | $440 | In-stock |
| 50mg | $770 | In-stock |
| 100mg | $1155 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-10896 |
| M.Wt: | 484.18 |
| Formula: | C19H20Br2N2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 170 mg/mL (351.11 mM; Need ultrasonic) |
JNJ-10397049 is a potent and selective orexin 2 receptor (OX2R) antagonist, with a pKi of 8.3. JNJ-10397049 is 600-fold selective for the OX2R over the OX1R[1][2].
In Vivo: JNJ-10397049 (10-30 mg/kg) decreases the latency for persistent sleep and increased nonrapid eye movement and rapid eye movement sleep time[2].
JNJ-10397049 blocks ethanol self-administration, place preference and reinstatement[3].
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