CAS No. : 69-05-6
(Synonyms: Mepacrine (dihydrochloride); SN-390 (dihydrochloride))
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Cat. No. : | HY-13735A |
M.Wt: | 472.88 |
Formula: | C23H32Cl3N3O |
Purity: | >98 % |
Solubility: | DMSO : ≥ 44 mg/mL (93.05 mM); H2O : 13.89 mg/mL (29.37 mM; Need ultrasonic) |
Quinacrine (Mepacrine) dihydrochloride is an orally bioavailable antimalarial agent, which possess anticancer effect both in vitro and vivo. Quinacrine dihydrochloride suppresses NF-κB and activate p53 signaling, which results in the induction of the apoptosis[1].
In Vitro: Quinacrine (5-20 μM; 24 hours) inhibits the growth of SGC-7901 cells[1].
Quinacrine (7.5 and 15 μM; 24 hours) induces apoptosis in SGC-7901 cells, which is associated with mitochondria-dependent signal pathway and involves p53 upregulation and caspase-3 activation pathway[1].
Quinacrine (15 μM; 24 hours) treatment significantly increased the levels of proapoptotic proteins, including cytochrome c, Bax, and p53, and decreased the levels of antiapoptotic protein Bcl-2, thus shifting the ratio of Bax/Bcl-2 in favor of apoptosis [1].
In Vivo: Quinacrine (100 mg/kg three times per week for two consecutive weeks) significantly suppresses circulating blast cells at days 30/31 and increases the median survival time (MST). Quinacrine does not decrease the body weight of treated animals at the tested dose[2].
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