CBR-5884


CAS No. : 681159-27-3

681159-27-3
Price and Availability of CAS No. : 681159-27-3
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5mg $72 In-stock
10mg $120 In-stock
25mg $252 In-stock
50mg $444 In-stock
100mg $792 In-stock
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Cat. No. : HY-100012
M.Wt: 336.39
Formula: C14H12N2O4S2
Purity: >98 %
Storage: at 20℃ 2 years
Solubility: DMSO
Introduction of 681159-27-3 :

CBR-5884 is a novel and noncompetitive 3-Phosphoglycerate dehydrogenase (PHGDH) inhibitor with IC50=33 μM). Decreases de novo serine synthesis in cancer cells. Inhibits proliferation of cancer cell lines and disrupted the oligomerization state of PHGDH. Biochemical characterization of the inhibitor revealed that it was a noncompetitive inhibitor that showed a time-dependent onset of inhibition and disrupted the oligomerization state of PHGDH. The identification of a small molecule inhibitor of PHGDH not only enables thorough preclinical evaluation of PHGDH as a target in cancers, but also provides a tool with which to study serine metabolism. [1]

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