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681159-27-3  Technical Data: Price and Availability of  Cas No:681159-27-3

Cas : 681159-27-3 M.Wt: 336.3861
Cas : 681159-27-3 Formula: C14H12N2O4S2
Cas : 681159-27-3 Purity: >98 %
Cas : 681159-27-3 Storage: at 20℃ 2 years
Cas : 681159-27-3 Solubility: 10 mM in DMSO
Cas : 681159-27-3 Name: CBR-5884
5mg/$60 In-stock
10mg/$100 In-stock
25mg/$210 In-stock
50mg/$370 In-stock
100mg/$660 In-stock
1g Get quote
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>10g Get quote
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681159-27-3  Data Sheet:
Introduction of 681159-27-3 :
CBR-5884 is a novel and noncompetitive 3-Phosphoglycerate dehydrogenase (PHGDH) inhibitor with IC50=33 μM). Decreases de novo serine synthesis in cancer cells. Inhibits proliferation of cancer cell lines and disrupted the oligomerization state of PHGDH. Biochemical characterization of the inhibitor revealed that it was a noncompetitive inhibitor that showed a time-dependent onset of inhibition and disrupted the oligomerization state of PHGDH. The identification of a small molecule inhibitor of PHGDH not only enables thorough preclinical evaluation of PHGDH as a target in cancers, but also provides a tool with which to study serine metabolism. [1]
References on 681159-27-3 :

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