CAS No. : 681159-27-3

Price and Availability of CAS No. : 681159-27-3
Size Price Stock
5mg $72 In-stock
10mg $120 In-stock
25mg $252 In-stock
50mg $444 In-stock
100mg $792 In-stock
200 mg Get quote
500 mg Get quote
We match the lowest price on market.

We offer a substantial discount on larger orders, please inquire via [email protected]

or Fax: (86)21-58955996

Inquiry for price and availability only. Please place your order via our email or fax.

Cat. No. : HY-100012
M.Wt: 336.39
Formula: C14H12N2O4S2
Purity: >98 %
Storage: at 20℃ 2 years
Solubility: DMSO : 50 mg/mL (148.64 mM; Need ultrasonic)
Introduction of 681159-27-3 :

CBR-5884 is a novel and noncompetitive 3-Phosphoglycerate dehydrogenase (PHGDH) inhibitor with IC50=33 μM). Decreases de novo serine synthesis in cancer cells. Inhibits proliferation of cancer cell lines and disrupted the oligomerization state of PHGDH. Biochemical characterization of the inhibitor revealed that it was a noncompetitive inhibitor that showed a time-dependent onset of inhibition and disrupted the oligomerization state of PHGDH. The identification of a small molecule inhibitor of PHGDH not only enables thorough preclinical evaluation of PHGDH as a target in cancers, but also provides a tool with which to study serine metabolism. [1]

Your information is safe with us.