JNJ-1661010


CAS No. : 681136-29-8

(Synonyms: Takeda-25)

681136-29-8
Price and Availability of CAS No. : 681136-29-8
Size Price Stock
5mg $50 In-stock
10mg $85 In-stock
25mg $175 In-stock
50mg $280 In-stock
100mg $450 In-stock
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Cat. No. : HY-N7062
M.Wt: 365.45
Formula: C19H19N5OS
Purity: >98 %
Solubility: DMSO : 100 mg/mL (273.64 mM; Need ultrasonic)
Introduction of 681136-29-8 :

JNJ-1661010 (Takeda-25) a potent and selective fatty acid amide hydrolase (FAAH) inhibitor with IC50s of 34 and 33 nM for rat FAAH and human FAAH, respectively. JNJ-1661010 can cross the blood-brain barrier and used as broad-spectrum analgesics[1][2]. IC50 & Target: IC50: 34 nM (rat FAAH) and 33 nM (human FAAH)[1] In Vivo: JNJ-1661010 (Takeda-25; i.p.; 50 mg/kg) diminishes thermal hyperalgesia in the inflammatory rat carrageenan paw model[2].
JNJ-1661010 (i.p.; 10 mg/kg) has a T1/2 of 35 mins, a CL of 0.032 mL/min/kg, and a Cmax of 1.58 μM for rats[1].

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