Tiodazosin
CAS No. : 66969-81-1
(Synonyms: BL-5111)
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| Cat. No. : | HY-100255 |
| M.Wt: | 431.47 |
| Formula: | C18H21N7O4S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Tiodazosin is a potent competitive postsynaptic alpha adrenergic receptor antagonist. IC50 & Target: alpha adrenergic receptor[1] In Vitro: Tiodazosin is a potent competitive postsynaptic alpha adrenergic receptor antagonist. In the mesenteric artery, Tiodazosin produces a parallel shift to the right in the concentration response curves to norepinephrine. A Schild plot constructed from two concentrations of Tiodazosin results in a pA2 value of 8.66 and a slope equal to -0.99. Tiodazosin inhibits contraction to norepinephrine in the portal vein and the inhibition results in a nonparallel inhibition of the norepinephrine concentration-response curve with a marked depression of maximal norepinephrine response[1].
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