Trehalose 6-behenate
CAS No. : 66755-19-9
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| Cat. No. : | HY-101871 |
| M.Wt: | 664.86 |
| Formula: | C34H64O12 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Trehalose 6-behenate is a Th1/Th17 skewing vaccine adjuvant. IC50 & Target: Trehalose 6-behenate (TDB) exerts its effect through binding to the macrophage-inducible C-type lectin Mincle, a pathogen recognition receptor (PRR) that recognises pathogen-associated molecular patterns (PAMPs). The potential of Th1/Th17 skewing adjuvants in vaccine development provides a very real incentive for better definition of the structural motifs required for Mincle binding. Mincle is highly conserved between mice and humans, with 85 % protein similarity. In addition to being a receptor for TDMs, Trehalose 6-behenate (TDB), and the spliceosome-associated protein (SAP)130 (which activates Mincle at a binding site different to that involved in carbohydrate recognition), Mincle is also a receptor for Candida albicans, Malassezia, and Fonsecaea pedrosoi[1].
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- Trehalose 6-behenate
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