Size | Price | Stock |
---|---|---|
250mg | $50 | In-stock |
500mg | $75 | In-stock |
1 g | Get quote | |
5 g | Get quote | |
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Cat. No. : | HY-N7073 |
M.Wt: | 1000.00 |
Formula: | N/A |
Purity: | >98 % |
Solubility: | DMSO : 120 mg/mL (Need ultrasonic) |
Silymarin is an extract of the milk thistle (Silybum marianum). Silymarin is an effective SARS-CoV-2 main protease (Mpro) inhibitor. Silymarin can significantly reduce tumor cell proliferation, angiogenesis as well as insulin resistance. Silymarin has the chemopreventive effect on hepatocellular carcinoma (HCC). Silymarin has the potential for COVID-19 research[1][2][4]. In Vitro: Silymarin (0-120 µg/ml; 24 hours) inhibits AGS cell viability, the viability of AGS cells is 77.9% in the presence of 20 µg/ml silymarin, 71.5% at 40 µg/ml, 59.8% at 60 µg/ml, 44.5% at 80 µg/ml, 35.3% at 100 µg/ml and 33.9% at 120 µg/ml[1].Silymarin (40-80 µg/ml; 24 hours) inhibits the migration of the AGS cells in a concentration-dependent manner. It inhibit migration of AGS cells 59.4% at 40 µg/ml and 21.7% at 80 µg/ml,respectively[1]. In Vivo: Silymarin (oral gavage; 10, 20, 50, 100, and 200 mg/kg) decreases the immobility time in a dose-dependent manner in forced swimming test (FST). It also lowers the immobility measure dose-dependently in tail suspension test (TST). Additionally, 50% of maximum response (ED50) of Silymarin is around 10 mg/kg. The dose 100 mg/kg proved the most effective dose in both the tests[3].
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