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HY-10355

CAS:612847-09-3

 (Synonyms  2H-Benzimidazol-2-one, 1,3-dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl]methyl]-4-piperidinyl]-)
612847-09-3  Technical Data: Price and Availability of  Cas No:612847-09-3

Cas : 612847-09-3 M.Wt: 551.64
Cas : 612847-09-3 Formula: C34H29N7O
Cas : 612847-09-3 Purity: >98 %
Cas : 612847-09-3 Storage: at 20℃ 2 years
Cas : 612847-09-3 Solubility: 10 mM in DMSO
Cas : 612847-09-3 Name: AKT inhibitor VIII
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612847-09-3  Data Sheet:
 
Introduction of 612847-09-3 :
Akt Inhibitor VIII is a cell-permeable quinoxaline compound that has been shown to potently, selectively, allosterically, and reversibly inhibit Akt1, Akt2, and Akt3 activity (IC50 = 58 nM, 210 nM, and 2.12 μM; respectively). IC50 value: 58/210/2120 nM(Akt1/2/3) Target: Akt Akt Inhibitor VIII does not exhibit any inhibitory effect against pleckstrin homology (PH) domain-lacking Akts, AGC family kinases, PKA, PKC or SGK. Akt Inhibitor VIII prevails over Akt1/Akt2-mediated resistance to chemotherapeutics in tumor cells and has been shown to block basal and stimulated phosphorylation/activation of Akt1/Akt2 in cultured cells and in mice.
 
References on 612847-09-3 :
 

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