HLCL-61
CAS No. : 586395-74-6
(Synonyms: 9-Ethyl-N-[(2-methoxyphenyl)methyl]-9H-carbazole-3-methanamine)
| Size | Price | Stock |
|---|---|---|
| 50mg | $420 | Get quote |
| 250mg | $1260 | Get quote |
| 500 mg | Get quote | |
| 1 g | Get quote | |
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| Cat. No. : | HY-100025 |
| M.Wt: | 344.45 |
| Formula: | C23H24N2O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
HLCL-61 is a first-in-class small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5).
IC50 & Target: Protein arginine methyltransferase 5[1]
In Vitro: HLCL-61 (1-100 μM; 24-72 hours) reduces cells growth at dose-dependent manner with IC50s of 14.12, 16.74, 6.3, 8.72 μM for MV4-11 cells, THP-1 cells, FLT3-WT blast, and FLT3-ITD blast, respectively[1].
HLCL-61 shows effective inhibition of symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples, starting at 12 h post-treatment and persisting after 48 h[1].
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