T16Ainh-A01
CAS No. : 552309-42-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $85 | In-stock |
| 10mg | $136 | In-stock |
| 50mg | $480 | In-stock |
| 100mg | $765 | In-stock |
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| Cat. No. : | HY-100612 |
| M.Wt: | 416.52 |
| Formula: | C19H20N4O3S2 |
| Purity: | >98 % |
| Solubility: | DMF : ≥ 10 mg/mL (24.01 mM); DMSO : ≥ 5 mg/mL (12.00 mM) |
T16Ainh-A01, an aminophenylthiazole, is a potent transmembrane protein 16A (TMEM16A) inhibitor, inhibiting TMEM16A-mediated chloride currents with an IC50 value of ~1 µM. TMEM16A (ANO1) functions as a calcium-activated chloride channel (CaCC)[1][2].
IC50 & Target: TMEM16A[1].
In Vitro: T16Ainh-A01 (0.3-30 μM) significantly reduces both inward and outward components of IClCa, and inhibits IClCa in RUICC without significantly affecting L-type Ca2+ current[1].
T16Ainh-A01 (10 μM) inhibits nearly completely TMEM16A chloride current (induced by 275 nM free calcium in the pipette) at all voltages, indicating a voltage-independent block mechanism[2].
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