Size | Price | Stock |
---|---|---|
5mg | $30 | In-stock |
10mg | $42 | In-stock |
25mg | $80 | In-stock |
50mg | $120 | In-stock |
100mg | $180 | In-stock |
200 mg | Get quote | |
500 mg | Get quote | |
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Cat. No. : | HY-100386 |
M.Wt: | 263.79 |
Formula: | C14H14ClNS |
Purity: | >98 % |
Solubility: | DMSO : ≥ 100 mg/mL |
Ticlopidine (PCR 5332), an antithrombotic proagent, acts as an allosteric, noncompetitive inhibitor of CD39 with the IC50 of 81.7 μM. Ticlopidine blocks several NTPDase isoenzymes with IC50s of 170 μM and 149 μM for NTPDase2 and NTPDase3, respectively. Ticlopidine is an inhibitor of CYP2C19 human liver cytochrome. Ticlopidine inhibits CYP2C9 and CYP3A4 with IC50s of 26.0 and 32.3 μM, respectively.
IC50 & Target:Cytochrome P450[1]
In Vitro:Ticlopidine exhibits activity against human CD39 with apparent Ki,app values of 14 µM[1].
Ticlopidine inhibits recombinant human CD39 expressed in COS-7-cells with the Ki value of 127±12 µM[1].
Growth rate is affected during the first days of culture, Ticlopidine (30 and 150 µM) reducing its effect in the following days[4].
In Vivo:Oral administration of Losartan with 10 mg/kg Ticlopidine significantly increases the AUC (by 65.0%), suggesting that Ticlopidine can effectively inhibit the metabolism of losartan in the intestine and/or liver[3].
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