Euscaphic acid
CAS No. : 53155-25-2
| Size | Price | Stock |
|---|---|---|
| 1mg | $150 | In-stock |
| 5mg | $430 | In-stock |
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| Cat. No. : | HY-N2566 |
| M.Wt: | 488.70 |
| Formula: | C30H48O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (511.56 mM; Need ultrasonic) |
Euscaphic acid, a DNA polymerase inhibitor, is a triterpene from the root of the R. alceaefolius Poir. Euscaphic inhibits calf DNA polymerase α (pol α) and rat DNA polymerase β (pol β) with IC50 values of 61 and 108 μM[1]. Euscaphic acid induces apoptosis[2]. IC50 & Target: IC50: 61 μM (calf DNA polymerase α); 108 μM (rat DNA polymerase β)[1]; apoptosis[2] In Vitro: Euscaphic acid induces apoptosis and cell cycle arrest in NPC cells by suppression of the PI3K/AKT/mTOR signaling pathway[2].
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