tans-4-Hydroxy-D-proline methyl ester (hydrochloride)
CAS No. : 481704-21-6
| Size | Price | Stock |
|---|---|---|
| 250mg | $6 | In-stock |
| 1g | $11 | In-stock |
| 5g | $48 | In-stock |
| 10g | $95 | In-stock |
| 25g | $134 | In-stock |
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| Cat. No. : | HY-W006629 |
| M.Wt: | 181.62 |
| Formula: | C6H12ClNO3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
tans-4-Hydroxy-D-proline methyl ester hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). tans-4-Hydroxy-D-proline methyl ester hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].
In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
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