Jervine
CAS No. : 469-59-0
(Synonyms: 11-Ketocyclopamine)
| Size | Price | Stock |
|---|---|---|
| 5mg | $81 | In-stock |
| 10mg | $150 | In-stock |
| 50mg | $685 | In-stock |
| 100mg | $1200 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-N0836 |
| M.Wt: | 425.60 |
| Formula: | C27H39NO3 |
| Purity: | >98 % |
| Solubility: | DMSO : 1 mg/mL (2.35 mM; Need ultrasonic) |
Jervine (11-Ketocyclopamine) is a potent Hedgehog (Hh) inhibitor with an IC50 of 500-700 nM[1]. Jervine is a natural teratogenic sterodial alkaloid from rhizomes of Veratrum nigrum. Jervine has anti-inflammatory and antioxidant properties[2].
IC50 & Target:IC50: 500-700 nM (Hedgehog)[1]
In Vitro: Jervine (40 μM; 6, 12 and 24 hours) inhibits Akt phosphorylation[3].
Jervine (40 μM; 2 hours) inhibits NF-jB activation decreased COX-2 overexpression and induced apoptosis[3].
In Vivo: Jervine (orally; 50-400 mg/kg) exerts 50.4-73.5% anti-inflammatory effects in carrageenan induced paw edema[2].
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