Teglarinad (chloride)
CAS No. : 432037-57-5
(Synonyms: GMX1777; EB-1627)
| Size | Price | Stock |
|---|---|---|
| 5mg | $400 | In-stock |
| 10mg | $680 | In-stock |
| 25mg | $1350 | In-stock |
| 50mg | $2200 | In-stock |
| 100mg | $3400 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-10080 |
| M.Wt: | 672.60 |
| Formula: | C30H43Cl2N5O8 |
| Purity: | >98 % |
| Solubility: | DMSO : 200 mg/mL (297.35 mM; Need ultrasonic) |
Teglarinad chloride (GMX1777) is a prodrug of GMX1778 (a nicotinamide phosphoribosyl transferase inhibitor). Teglarinad chloride exhibits antitumor activity in mice can be attributed to inhibition of NAMPT. Teglarinad chloride also enhances radiation efficacy, mediated by interference with DNA repair and antiangiogenesis[1][2].
In Vivo: GMX1777 (75 mg/kg; 24 h intravenous infusion) causes tumor regression in the IM-9 model, a small-cell lung cancer (SHP-77) model, and a colon carcinoma (HCT-116) model[2].
GMX1777 (50-100 mg/kg/d, i.m. for 5 d) with or without local tumor radiotherapy is effective for both FaDu and C666-1 tumors in vivo[1].
GMX1777 (25-400 mg/kg; 24 h intravenous infusion) is quickly converted to GMX1778 in plasma of mice with a half-life of GMX1777 less than 0.7 h[2].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- Teglarinad (chloride)
- Cat. No.:
- HY-10080
- Quantity:
Your information is safe with us.