Qc1
CAS No. : 403718-45-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $130 | In-stock |
| 10mg | $210 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-103391 |
| M.Wt: | 455.45 |
| Formula: | C23H16F3N3O2S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Qc1 is a reversible and noncompetitive threonine dehydrogenase (TDH) inhibitor. Qc1 can be used for the research of Metabolic disease[1][2].
IC50 & Target: TDH[1]
In Vitro: Qc1 (10 μM; 2~24 hours; ES cells) shows that a substantial fraction of the total LC3 protein is in the LC3-I (cytoplasmic) form. After 16 h of TDH inhibition, most LC3 is converted to the LC3-II (lipid-modified) form, indicative of increased autophagic activity[2].
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Qc1 blocks the charging of tetrahydrofolate. Qc1 prevents threonine dehydrogenase from catabolizing threonine into acetyl-CoA and glycine[1][2].
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