JNJ-5207852
CAS No. : 398473-34-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $90 | In-stock |
| 10mg | $140 | In-stock |
| 50mg | $580 | In-stock |
| 100mg | $980 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-12190 |
| M.Wt: | 316.48 |
| Formula: | C20H32N2O |
| Purity: | >98 % |
| Solubility: | DMSO : 77.5 mg/mL (244.88 mM; Need ultrasonic) |
JNJ-5207852 is a selective and potent histamine H3 receptor (H3R) antagonist, with pKis of 8.9, 9.24 for rat and human H3R, respectively. IC50 & Target: pKi: 8.9 (rat H3R), 9.24 (human H3R)[1][2]. In Vivo: JNJ-5207852 (1-10mg/kg s.c.) increases time spent awake and decreases REM sleep and slow-wave sleep, but fails to have an effect on wakefulness or sleep in H3 receptor knockout mice. The wake promoting effects of this H3 receptor antagonist are not associated with hypermotility. A 4-week daily treatment of mice with JNJ-5207852 (10 mg/kg i.p.) does not lead to a change in body weight. JNJ-5207852 is extensively absorbed after oral administration and reaches high brain levels[1].
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