Mirdametinib (GMP)
CAS No. : 391210-10-9
(Synonyms: PD0325901 (GMP); PD325901 (GMP))
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| Cat. No. : | HY-10254G |
| M.Wt: | 482.19 |
| Formula: | C16H14F3IN2O4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Mirdametinib (PD0325901) (GMP) is Mirdametinib (HY-10254) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Mirdametinib is an orally active, selective and non-ATP-competitive MEK inhibitor[1][2][3]. In Vitro:Mirdametinib (250 nM; 7 d) induces differentiation of cardiac PCs into vascular smooth muscle cell (VSMC)-like cells[1]. Mirdametinib (10 μM; 4 d) induces oligodendrocyte precursor cells (OPC) to oligodendrocytes (OL) differentiation[2]. Mirdametinib enhances embryonic stem cells (ESC) self-renewal capacity both by key regulatory genes and ES cell-specific miRNA, which in turn influences ESC self-renewal and cellular differentiation[3].
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