Size | Price | Stock |
---|---|---|
5mg | $88 | In-stock |
10mg | $132 | In-stock |
50mg | $495 | In-stock |
100 mg | Get quote | |
200 mg | Get quote | |
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Cat. No. : | HY-100675 |
M.Wt: | 408.29 |
Formula: | C17H19Cl2N7O |
Purity: | >98 % |
Solubility: | DMSO : 100 mg/mL (244.92 mM; Need ultrasonic) |
JTE-013 is a potent and specific S1P2 (Sphingosine-1-Phosphate 2; EDG-5) antagonist. JTE-013 inhibits the specific binding of radiolabeled S1P to human and rat S1P2 with IC50s of 17 nM and 22 nM, respectively[1].
IC50 & Target: IC50: 17 nM (S1P2 for human) and 22 nM (S1P2 for rat)[1]
In Vitro: JTE-013 (50-200 μM; 1-3 days) reduced cell viability[1].
JTE-013 (10-1000 nM; 30 mins) reverses S1P-induced Akt inhibition and inhibits S1P-induced ERK activation[1].
JTE-013 displays 4.2% inhibition of S1P3 and does not antagonize S1P1 at concentrations up to 10 μM[1].
In Vivo: JTE-013 (gavage; 30 mg/kg daily for 14 consecutive days) reduces tumor size and tumor weight[1].
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