TCS-OX2-29
CAS No. : 372523-75-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $80 | In-stock |
| 10mg | $120 | In-stock |
| 25mg | $230 | In-stock |
| 50mg | $340 | In-stock |
| 100mg | $600 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-100452 |
| M.Wt: | 397.51 |
| Formula: | C23H31N3O3 |
| Purity: | >98 % |
| Solubility: | Ethanol : 25 mg/mL (ultrasonic);DMSO : 25 mg/mL (ultrasonic) |
TCS-OX2-29 is a potent, high affinities and selective orexin-2 receptor (OX2R) antagonist with an IC50 value of 40 nM and a pKI value of 7.5. TCS-OX2-29 displays ~250-fold selectivity for OX2 over OX1[1][2]. IC50 & Target:IC50: 40 nM (OX2R)[1]; pKi: 7.5 (OX2R)[2] In Vitro:TCS-OX2-29 inhibits orexin A induced IP3 accumulation and ERK1/2 phosphorylation in CHO cells transfected with the OX2 receptor[2]. In Vivo:TCS-OX2-29 (5-10 mg/kg; intraperitoneal injection; adult male NMRI mice) treatment suppresses conditioned place preference (CPP) acquisition and expression in both naïve and dependent mice significantly[2].
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- TCS-OX2-29
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