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 (Synonyms  BMS-387032;SNS 032;SNS032;BMS 387032;BMS387032)
345627-80-7  Technical Data: Price and Availability of  Cas No:345627-80-7

Cas : 345627-80-7 M.Wt: 380.53
Cas : 345627-80-7 Formula: C17H24N4O2S2
Cas : 345627-80-7 Purity: >98 %
Cas : 345627-80-7 Storage: at 20℃ 2 years
Cas : 345627-80-7 Solubility: 10 mM in DMSO
Cas : 345627-80-7 Name: SNS-032
5mg/$86 In-stock
10mg/$126 In-stock
50mg/$459 In-stock
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5g Get quote
>10g Get quote
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345627-80-7  Data Sheet:
Introduction of 345627-80-7 :
SNS-032(BMS-387032) is a potent inhibitor of cyclin-dependent kinases (cdks) 9, 2 and 7 (IC50 values are 4, 38 and 62 nM respectively). IC50 Value: 38 nM(for CDK2); 62 nM(for CDK7); 4 nM(for CDK9) Target: CDK in vitro: BMS-387032 displays no activity against 190 additional kinases (IC50 >1000 nM). BMS-387032 arrests the cell cycle at G2/M; inhibits transcription, proliferation and colony formation, and induces apoptosis in RPMI-8226 multiple myeloma cells. BMS-387032 prevents tumor cell-induced VEGF secretion and in vitro angiogenesis. SNS-032 inhibits three dimensional capillary network formations of endothelial cells. SNS-032 completely prevents U87MG cell–mediated capillary formation of HUVECs. In addition, SNS-032 significantly prevents the production of VEGF in both cell lines, SNS-032 prevents in vitro angiogenesis, and this action is attributable to blocking of VEGF. Preclinical studies have shown that SNS-032 induces cell cycle arrest and apoptosis across multiple cell lines. in vivo: SNS-032 prevents tumor cell-induced VEGF secretion in a tumor coculture model. SNS-032, a new CDK inhibitor, is more selective and less cytotoxic and has been shown to prolong stable disease in solid tumors.
References on 345627-80-7 :

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